Q: Who was the first American First Lady to run for public office?
A: Hillary Rodham Clinton became the first U.S. First Lady to run for office when she ran for U.S. Senate in 2000.
Washington Area Women's Foundation
Q: Who was the first American First Lady to run for public office?
A: Hillary Rodham Clinton became the first U.S. First Lady to run for office when she ran for U.S. Senate in 2000.